Targeted Protein Degradation: From Chemical Biology to Drug Discovery
Deadline Aug 2 2019 11:59 PM (EDT)
Description

Event Date: September 24, 2019
Deadline to Submit Abstracts: August 2, 2019

The majority of disease-causing proteins are not amenable to modulation by conventional pharmacological methods. In recent years an alternative therapeutic strategy known as targeted protein degradation has emerged with the potential to inhibit these “undruggable” proteins. This method utilizes chimeric, tripartite molecules that bind to the protein of interest, thereby promoting its polyubiquitination and subsequent proteosomal degradation. These chimeras can be designed to target a wide range of proteins, and offer the advantage of completely ablating both catalytic and scaffolding functions. Moreover, recent data indicates that these molecules can be developed into effective oral agents, making them therapeutically viable.

This symposium will highlight the latest advances in the field of targeted protein degradation and showcase the benefits of this approach over traditional small molecule inhibitors.

To register for this event, please visit the main website at: http://www.nyas.org/Protacs2019

Apply

Targeted Protein Degradation: From Chemical Biology to Drug Discovery


Event Date: September 24, 2019
Deadline to Submit Abstracts: August 2, 2019

The majority of disease-causing proteins are not amenable to modulation by conventional pharmacological methods. In recent years an alternative therapeutic strategy known as targeted protein degradation has emerged with the potential to inhibit these “undruggable” proteins. This method utilizes chimeric, tripartite molecules that bind to the protein of interest, thereby promoting its polyubiquitination and subsequent proteosomal degradation. These chimeras can be designed to target a wide range of proteins, and offer the advantage of completely ablating both catalytic and scaffolding functions. Moreover, recent data indicates that these molecules can be developed into effective oral agents, making them therapeutically viable.

This symposium will highlight the latest advances in the field of targeted protein degradation and showcase the benefits of this approach over traditional small molecule inhibitors.

To register for this event, please visit the main website at: http://www.nyas.org/Protacs2019

Apply
Deadline
Aug 2 2019 11:59 PM (EDT)