Next Generation Organoids for Biomedical Research and Drug Discovery
Event Date: November 12, 2019
Deadline to Submit Abstracts: September 17, 2019
Recent advances in 3D culture technology have allowed embryonic and adult mammalian stem cells to exhibit their remarkable self-organizing properties, with the resulting organoids reflecting key structural and functional properties of organs — including kidney, lung, gut, brain and retina. By mimicking the microstructures and biological functions of target organs, organoids complement or improve upon current multiscaled drug-testing platforms including in vitro molecular assays, cell platforms, and in vivo models, and modelling human organ development and various pathologies “in a dish.’’ The technology is currently being extended to develop multi-organ models that enable precise control of multicellular activities, extracellular matrix (ECM) compositions, spatial distributions of cells, architectural organizations of ECM, and environmental cues.
These engineered human organs are a remarkable tool with the potential to facilitate studies that better predict drug efficacy and thereby reduce cost, time, and failure rates in clinical trials. Further, patient-derived organoids hold promise for personalized medicine, as they have the potential to produce individualized predictions of drug response. This symposium will feature discussions on the science behind organoid models, along with their many applications in health and disease.
To register for this event, please visit the main website at: https://www.nyas.org/events/2019/next-generation-organoids-for-biomedical-research-and-drug-discovery/